Science - Thorasys

Beyond Spirometry: Why Oscillometry may be the key to Pre-COPD.

Widespread structural and ventilation defects exist in the lungs of most COPD patients. Learn how Oscillometry may be the key to understanding early symptoms.

Oscillometry for acute asthma in the pediatric emergency department

Study aim: Assess the feasibility and responsiveness of oscillometry in the emergency department management of children with acute asthma exacerbations.

Comparing lung oscillometry with a novel, portable flow interrupter device to measure lung mechanics

The aim was to examine the concordance between respiratory resistance measured with the REOM with that measured by oscillometry on the tremoflo.

Effect of inhaled corticosteroids on small airways in asthma: Investigation using impulse oscillometry

HFA-BDP is an effective treatment of small airways in asthma. Prolonged treatment provides a progressive effect over time, which is associated with an attenuation of airway responsiveness.

Effect of extrafine formulation of BDP/FF inhaler on asthma control, small airway function and airway inflammation

Study aim: assess the effect of extrafine Beclometasone dipropionate/Formoterol fumarate (BDP/FF) in the control of symptoms, lung function and lung inflammation in patients with asthma.

Monitoring lung transplant patients with Airwave Oscillometry [Webinar]

Are you aware that Airwave Oscillometry has been shown to be more sensitive than spirometry in detecting changes in lung function related to lung transplants results?

Home-based Forced Oscillation Technique Day-to-Day Variability in Pediatric Asthma

An approach to better characterize asthma exacerbations & detect changes in asthma control

Oscillometry by GOLD Stage and Grade, and Correlation With Symptoms in Community Practice COPD

OS is feasible in community practice. In this small COPD population, OS parameters worsen more with increasing GOLD stage than grade and correlate better than spirometry with CAT but not mMRC.

Oscillometry Small Airways Phenotypes are Predictive of GOLD Classification, Lung Function & Emphysema in COPD

Oscillometry Small Airways Phenotypes Are Predictive of GOLD Classification, Lung Function and Emphysema but Not Chronic Bronchitis in Community Practice COPD.

Comparison of Oscillometry (FOT) & Spirometry in COPD and Alpha-1-Antitrypsin Deficient Patients

Forced oscillation technique has been widely applied to physiological assessment in obstructive lung diseases, but it is unclear whether the impedance values measured with different devices are identi

Respiratory system reactance reflects communicating lung volume in COPD

These findings confirm the role of reduced communicating lung volume as an important determinant of Xrs and therefore advance our understanding and interpretation of FOT measurements in COPD.

The Effect of Artefacts on Variability and Repeatability of Respiratory Impedance in Healthy Adults

Respiratory impedance measured by forced oscillometry has been found to be highly variable due to repeated fluctuations of airway diameter in diseased states such as asthma and COPD.

Comparison of Three Devices for Respiratory Impedance Measurement Using Forced Oscillation Technique

FOT has been widely applied to physiological assessment in obstructive lung diseases, but it's unclear whether the impedance values measured with different devices are identical

Firefighting Self-Contained Breathing Apparatus & Airway Hyperresponsiveness

Study investigating the pattern of peripheral airway function change with Pulmonary graft versus host disease (pGvHD) in children following Bone Marrow Transplant (BMT).

Applications of oscillometry in clinical research and practice

It was concluded that oscillometry has several advantages over spirometry, most notably, with novel data being shown, its sensitivity allowing early detection of small airways disease [...].

Changes in Peripheral Airway Function with Pulmonary Graft Vs. Host Disease in Bone Marrow Transplant Patients

Significant abnormalties in peripheral airway function occurred in both cases of pGVHD with the same pattern of abnormality.

Weight-Loss- and Bronchodilator-Induced Changes in Upright and Supine Respiratory System Mechanics

The contribution of central and peripheral lung mechanics to the measured changes in total respiratory mechanics is poorly understood.

Oscillometry for early detection of bronchiolitis obliterans after hematogenous stem cell transplant

Study compareing the sensitivity of FO with spirometry in early detection of lung function decline post HSCT.

Longitudinal Utility of Peripheral Airway Function Tests in Pulmonary Graft Vs. Host Disease in Pediatric BMT Patients

Longitudinal Utility of Peripheral Airway Function Tests in Pulmonary Graft Vs. Host Disease in Pediatric Bone Marrow Transplant Patients.

Development of Quality Assurance and Quality Control Guidelines for Respiratory Oscillometry

Quality assurance and quality control guidelines for respiratory oscillometry testing remain limited, althought they are essential for oscillometry to be used as a diagnostic PFT in a clinical setting

Oscillometric Measurements in Nigerian Children Born to Women of A Randomized Controlled Ethanol Cookstove

Lung function is affected by exposure to household air pollution (HAP). We investigated the impact of pre- and post-natal exposure to HAP on lung growth of children starting at the age of 2 years.

High inspired oxygen fraction impairs lung volume and ventilation heterogeneity in healthy children

Although a high inspired oxygen fraction (FiO2) is commonly used in paediatric anaesthesia, the impact on postoperative lung function is unclear.

Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates

Determine normative data by FOT in non-sedated normal term neonates and test the hypothesis that infants with TTN have higher resistance (R) and lower reactance (X) on day 1.

Effects of Oxygen Concentration on Respiratory Physiology in Pediatric Anesthesia [French only]

Il est courant d’administrer de hautes fractions inspirées d’oxygène lors d'anesthésie mais les répercussions postopératoires de cette hyperoxygénation sur les fonctions pulmonaires sont incertaines.

FOT by GOLD Classification, and Correlation with PFTs & PROs in Community Practice COPD

Assessment of the feasibility of using FOT in community practice, FOT parameters by GOLD classification, and the relationship of FOT parameters with PFTs, COPD assessment test and mMRC dyspnea scale.

Changes in Lung Function and FOT Parameters Following BT in Patients with Refractory Asthma

Assessment of lung function during tidal breathing with oscillometry to measure respiratory impedance may better reflect the clinical improvements reported.

Assessment of Intrabreath Mechanics from Conventional Oscillometry Measurements

Rationale recent advance in oscillometry have revealed the diagnostic potential of intra-breath changes in the mechanical impedence of the respiratory system.

Airwave Oscillometry in the diagnosis and monitoring of respiratory disease [webinar]

Learn how Airwave Oscillometry can help your clinical practice in the assessment of respiratory disease with Brian Lipworth, MD and clinical professor at the University of Dundee.

Lung function monitoring in the era of respiratory pandemics

The ongoing pandemic has caused many clinics to stop using standard spirometry for the fear of aerosol transmission, however, Oscillometry technology is an alternative to test lung function.

Non-invasive measure of mechanics & conventional respiratory in animals by Airwave Oscillometry

An Airwave Oscillometry system was used to concomitantly assess Rrs and conventional respiratory parameters before and after intravenous treatment with a bronchoactive agent.

Within-breath resistance & reactance in two forced oscillation technique devices

Comparision of total, inspiratory and expiratory resistance (Rrs) and reactance (Xrs) between two commercial forced oscillation technique (FOT) devices.

Oscillometry changes with body position and correlates with TLC and lung density

Study aiming to determine body position effect on oscillometry and if pulmonary function test or lung density would predict any changes on COPD and heathy subjects.

Oscillometry system comparison in phantoms and humans

Study comparing an Impulse Oscillometry System (IOS; CareFusion) and an Airwave Oscillometry System (tremoFlo; THORASYS) in phantoms & humans.

Statistical model to estimate lung density utilizing oscillometry, biometrics, PROs & PFT

A reasonable estimate of lung density, and hence emphysema, is possible by means of non-radiologic parameters.

Assessing response to methacholine challenges using a new forced oscillation device

Study comparing FEV1 vs FOT responses to a methacholine challenge using a commercial FOT device, and propose potential cut-points that define a positive response.

Patient Reported Outcomes Correlate Better with Intra-Breath than with Whole-Breath FOT Parameters

Validation of these findings in larger cohorts would support the usefulness of IB FOT parameters for the evaluation of COPD.

Airway smooth muscle tone increases airway responsiveness in healthy young adults

Study assessing the effect of tone on airway responsiveness in humans. All subjects were healthy nonasthmatics without a history of respiratory disease.

Frequency dependence of resistance using patient-specific 3D physical model & a computational model

Study evaluating the central airway contribution to frequency dependence of resistance, measured with Impulse Oscillometry and Sinusoidal Forced Oscillations.

Assessment of Airway Distensibility by the Forced Oscillation Technique

Study investigating the reproducibility of airway distensibility measured by FOT & to assessing whether the method could be simplified to increase feasibility.

Comparison of two methods of determining lung de-recruitment, using the forced oscillation technique

This study aims to determine if a slow vital capacity maneuver can be used instead of this deflation maneuver and compare it to existing more complex techniques.

Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways

The present study examines the acute effects of e-cigarette aerosol inhalation, with and without nicotine, on vascular and pulmonary function in healthy volunteers.

Comparison of Forced and Impulse Oscillometry Measurements

We compared two commercially available FOT devices: Impulse Oscillometry System and TremoFlo FOT in clinical adult population of healthy controls, asymptomatic smokers and individuals with asthma.

Comparison of oscillometry devices using active mechanical test loads

There are concerns about the comparability betwen oscillometry devices. This study compares the performances of oscillometers in the measurement of mechanical test loads.

Towards Prepared mums for a healthy start, an intervention for women with overweight & a child wish

A preconception lifestyle intervention might be more effective to reduce perinatal complications.This study aims to evaluate the effect of a lifestyle intervention on lifestyle behaviour change.

Differences in forced oscillation between mouthpiece and mask

Study measuring resistance at 5Hz (R5), frequency dependence of resistance (R5-20) and the Reactance area (Ax) in adults breathing through a mouthpiece or mask.

Tracking Respiratory Mechanics With Oscillometry: Introduction of Time-Varying Error

We introduce the error arising from respiratory time variation, termed the time-varying error & demonstrate how TVE increases with increasing breathing rate independent of breathing noise amplitude.

Long‐term morbidity of respiratory viral infections during chemotherapy in children with leukaemia

Study evaluating the long‐term pulmonary morbidity of respiratory viral infections during chemotherapy in children with acute lymphoblastic leukemia using spirometry, plethysmography and oscillometry.

Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique

Airway resistance and reactance at 5 Hz and VE were measured prior to forced expiratory volume in 1 s (FEV1) before & up to 20 min after a standard EC in people with asthma & healthy controls.

Early detection of changes in lung mechanics with oscillometry following bariatric surgery

[French only] Étude visant à vérifier si des modifications précoces de la mécanique pulmonaire consécutives à la perte de poids sont détectables par l’oscillométrie.

Discrepancy between in vivo and in vitro comparisons of forced oscillation devices

Subjects performed three measurements during tidal breathing on the four devices in random order. Total, inspiratory and expiratory Rrs and Xrs were calculated and compared.

Improvement in lung mechanics with bariatric surgery affects bronchodilator responsiveness & sleep quality

The study aims to quantify the degree of weight loss-induced improvements in respiratory system mechanics in both upright and supine positions, using spirometry, plethysmography, and oscillometry.

Journal of Clinical Monitoring and Computing 2017 end of year summary: respiration

This paper reviews 32 papers or commentaries published in Journal of Clinical Monitoring and Computing in 2016, within the field of respiration.

Small airways effects of exposure to wood smoke

The aim of this study was to investigate whether controlled exposure to wood smoke generated from incomplete soot-rich combustion would increase small airway resistance and reactance.

Airway Oscillometry Detects Spirometric-Silent Episodes of Acute Cellular Rejection

Airway oscillometry is a lung function test that detects peripheral airway inhomogeneity with greater sensitivity than spirometry. What is the role of oscillometry in patient monitoring post-transplan

The Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal & Child Health

We developed a couple-child cohort relying on deep phenotyping and extended personal exposure assessment aiming to better characterize the effects of components of the exposome.

Respiratory function in healthy Emirati children using forced oscillations

Lung function using FOT was assessed in healthy Emirati children aged 4‐12 years. Using a validated questionnaires general medical and respiratory histories were obtained.

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

Study on respiratory risks following exposure to short periods of poor air quality in infants. Results: it could be associated with long‐term impairment of lung reactance.

Recent Diagnosis Techniques in Pediatric Asthma: Impulse Oscillometry in Preschool Asthma

Objective measures of lung function are important in the diagnosis and management of asthma, yet most preschoolers cannot perform spirometry.

Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates

FOT in neonates distinguishes normal control infants from those with TTN on postnatal day 1. Oscillometry is a non-invasive, longitudinal technique to assess lung mechanics in newborns.

Discordant and concordant Forced Oscillation Technique / spirometry phenotypes in a COPD population

Forced Oscillation Technique staged COPD correlates better with patient reported outcomes than spirometry. Our data suggests that up to 19% of COPD subjects may be misclassified using spirometry.

Bronchodilator responses in respiratory impedance, hyperinflation and gas trapping in COPD

The relationships between changes in resistance and reactance, and changes in hyperinflation and gas trapping, following long-acting bronchodilator (LA-BD) have not been studied yet.

What can we learn about COPD from impulse oscillometry?

Impulse oscillometry (IOS) is the most commonly used forced oscillation technique, and relatively little is known about its application in COPD.

Contribution and distribution of emphysema & small airways disease in COPD described by CT analysis

This study aims to compare two CT quantitative analysis techniques, disease probability measure and parametric response mapping, and assess their relationship with specific physiological measures.

Oscillometry in Chronic Obstructive Lung Disease: impulse oscillometry & tremoflo devices

Comparison of a new respiratory oscillometry instrument, the tremoflo, with Impulse Oscillometry (IOS) on patients with diagnosis of chronic obstructive lung disease (COPD) and healthy subjects.

Duration impacts variability measured by the forced oscillation in healthy, asthma & COPD subjects

FOT measurements are useful for measuring lung function of people who have difficulty performing spirometry, since it requires tidal breathing without need for any forced manoeuvres.

Effects of nicotine/flavor-free e-cigarette use on lung functions in healthy & asthmatic individuals

Electronic cigarette is available everywhere and is aggressively marketed as a safe way to stop smoking. Reality is that we do not know the consequences of vaping on pulmonary health.

Effect of tralokinumab on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma

Researchers aimed to evaluate whether tralokinumab would have an effect on airway eosinophilic infiltration, blood and sputum eosinophil concentrations, eosinophil activation, and airway remodelling.

Oscillometry and pulmonary MRI measurements of ventilation heterogeneity in obstructive lung disease

In 100 patients ventilation heterogeneity and respiratory system impedance were correlated and both were independently related to quality of life scores and asthma control.

Sputum Eosinophilia and Magnetic Resonance Imaging (MRI) Ventilation Heterogeneity in Severe Asthma

The manucript investigates the contribution of eosinophilic bronchitis and smooth muscle dysfunction to magnetic resonance imaging (MRI) ventilation heterogeneity in patients with severe asthma.

Nasopharyngeal isolates and their clinical impact on young children with asthma: a pilot study

Researchers investigated the nasopharyngeal colonization in children with asthma to determine the prevalence of pathogens and their contribution to respiratory symptoms and airway resistance.

Reduced lung elastic recoil and fixed airflow obstruction in asthma

Fixed airflow obstruction (FAO) in asthma occurs despite optimal inhaled treatment and no smoking history, and remains a significant problem, particularly with increasing age and duration of asthma.

P17 Dietary nitrate supplementation: Implications for the assessment of airway health in athletes

The primary aim of this study was to evaluate the effect of acute dietary nitrate supplementation on FeNO and resting pulmonary function parameters.

IOS vs AOS: Comparative Bias in Respiratory Impedance Measurements

The forced oscillation technique (FOT) measures respiratory impedance during normal tidal breathing. This study compares IOS & AOS devices in patients with asthma & COPD.

Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD

Study of the relationships between parameters measurements in ex-smokers and non-smokers with chronic‐obstructive‐pulmonary‐disease (COPD) or asthma

Interdevice agreement in respiratory resistance values by oscillometry in asthmatic children

Spirometry remains the gold standard for the diagnosis and monitoring of patients with asthma. However, oscillometry, an effort-independent technique, has been shown to be responsive to change.

Measuring the effects of bronchial thermoplasty (BT) using oscillometry (AOS)

Bronchial thermoplasty (BT) is helping patients with severe asthma, but no improvement captured by spirometry. This study evaluates the response to BT using oscillometry.

Bronchodilator Response Assessed by the Forced Oscillation Technique Identifies Poor Asthma Control

The manuscripts presents the comparison of BDR cutoffs by using different methods which are FOT and spirometry.

Airwave oscillometry and patient-reported outcomes in persistent asthma

Airwave oscillometry measurements strongly correlate with IOS and quantify the degree of small airways dysfunction (SAD) [...]

The effect of the extrafine formulation of BDP/FF inhaler on Mexican asthmatic patients

This retrospective analysis reinforces the concept of maintenance treatment focused on inflammation background of the disease and the need of bronchodilator effect also in Mexican population.

Early detection of exacerbation in patients with respiratory diseases including COVID-19

By detecting small airway dysfunction before it becomes symptomatically apparent, Oscillometry might be able to separate COVID-19 patients whose peripheral lungs are affected.

Beyond spirometry

For many decades, requiring patients to make forced, maximal exhalations to measure their expiratory volumes and flows, has been the standard of care for pulmonary function testing (PFT). However, des

Small Airways Dysfunction in Asthma: Evaluation and Management

Reference equations for respiratory system resistance and reactance in adults

Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years

Transient reference values for impulse oscillometry for children aged 3–18 years

Respiratory impedance in healthy subjects: baseline values and bronchodilator response

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The tremoflo has been used in multiple scientific studies across the world. Learn more about its performance here.

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