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Abstract

Background

Functional assessment of small airways in young children with bronchiolitis obliterans (BO) is challenging due to their relative inaccessibility and the generally poor lung function test performance of these patients. We analyze the correlation between impulse oscillometry (IOS), spirometry, and plethysmographic parameters in pediatric BO patients.

Methods

A total of 89 IOS assessments of pediatric BO patients or children without lung disease were included, and the relationship between pulmonary function tests (PFTs) and diagnostic performance were analyzed.

Results

R5, R5-20, X5, and AX were statistically significantly worse in the BO group. In Spearman’s correlation analysis, AX and R5 showed the strongest correlation with conventional PFT parameters, and AX was the variable with the highest relative correlation with FEV1, FEF25-75%, and both measures of plethysmographic resistance. Receiver operating curve analysis highlighted AX and Raw% pred as the most optimal parameters for BO diagnostic performance with areas under curve of 0.811 and 0.827, respectively.

Conclusion

The AX and R5 parameters can be useful in identifying the severity of airway obstruction in children with BO, and IOS more generally can accurately detect pathological obliteration of small airways in pediatric BO patients.



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Source

Lee HJ, Kim K, Kim S koo, Lee JW, Yoon J-S, Chung NG, et al. Relationship between impulse oscillometry system and conventional lung function test for diagnosis of bronchiolitis obliterans in children. Authorea Prepr [Internet]. 2021 Feb 9 [cited 2021 Aug 3];1–7