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Intra-breath oscillometry has been proposed as a more sensitive measure of airway obstruction and respiratory mechanics compared to conventional spectral oscillometry outcomes in children with recurrent wheeze. It is unknown whether intra-breath oscillometry detects airway obstruction in children born preterm. We aimed to assess intra-breath and spectral oscillometry measures in preterm and term-born children.


Spectral and intra-breath oscillometry was measured using the tremoflo device (Thorasys Inc. Montreal, QC) before and after 400 µg salbutamol in children born very preterm (<32 weeks gestation) and at term (>37 weeks gestation); aged 6-12 years.


Oscillometry was measured at a mean age of 10.6 years in 20 term-born and 65 preterm-born children, of whom 15 had a neonatal diagnosis of bronchopulmonary dysplasia. At baseline, spectral oscillometry measures (R5, X5 and AX) were significantly different between preterm- and term-born children, however intra-breath outcomes (∆R10, ∆X10) were not (Table 1). A significant bronchodilator response (-32% or greater change in R5) was present in 20/65 (30.7%) preterm-born children and 4/20 (20.0%) term-born children (p>0.05).


Spectral oscillometry differentiated preterm from term-born children, whereas intra-breath measures did not.

The articles include uses of tremoflo products or describes research devices that may not have been cleared by FDA

Urs R, Evans D, Hall G, Simpson S. Intra-breath and spectral oscillometry in preterm-born children. Eur Respir J [Internet]. 2020 Sep 7 [cited 2020 Nov 2];56(suppl 64):1181