Entrées par Evgeny Grachev

Beyond spirometry

[En anglais seulement] Why measuring FEV1 and FVC may no longer be enough. Leslie Gold, M.Sc., and Lennart Lundblad, PhD & Associate Professor, 2018 Background For many decades, requiring patients to make forced, maximal exhalations to measure their expiratory volumes and flows, has been the standard of care for pulmonary function testing (PFT). However, despite […]

Techniques of assessing small airways dysfunction

The small airways are defined as those less than 2 mm in diameter. They are a major site of pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) and asthma. The small airways are frequently involved early in the course of these diseases, with significant pathology demonstrable often before the onset of symptoms or changes in spirometry and imaging. Despite their importance, they have proven relatively difficult to study. This is in part due to their relative inaccessibility to biopsy and their small size which makes their imaging difficult. Traditional lung function tests may only become abnormal once there is a significant burden of disease within them. This has led to the term ‘the quiet zone’ of the lung. In recent years, more specialised tests have been developed which may detect these changes earlier, perhaps offering the possibility of earlier diagnosis and intervention. These tests are now moving from the realms of clinical research laboratories into routine clinical practice and are increasingly useful in the diagnosis and monitoring of respiratory diseases. This article gives an overview of small airways physiology and some of the routine and more advanced tests of airway function.

Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years

Claudia Calogero MD, Shannon J. Simpson PhD, Enrico Lombardi MD, Niccolò Parri MD, Barbara Cuomo MD, Massimo Palumbo MD, Maurizio de Martino MD, Claire Shackleton BSc (Hons), Maureen Verheggen MMedSc, Tania Gavidia MIH, Peter J. Franklin PhD, Merci M.H. Kusel MBBS, PhD, Judy Park MBiostat, Peter D. Sly DSc, Prof. Graham L Hall PhD   Abstract Background The forced oscillation technique (FOT) can be used in children as young […]

Transient reference values for impulse oscillometry for children aged 3–18 years

Bożena Nowowiejska MD, Waldemar Tomalak PhD, Jakub Radliński PhD, Grzegorz Siergiejko MD, Wojciech Latawiec PhD, Maciej Kaczmarski MD, PhD   Abstract Impulse oscillometry (IOS) is a technique of assessing mechanical properties of respiratory system by means of measuring resistances and reactances in a number of frequencies during tidal breathing. It is especially useful in preschool children, however has […]

Respiratory impedance in healthy subjects: baseline values and bronchodilator response

Ellie Oostveen1, Krisztina Boda2, Chris P.M. van der Grinten3, Alan L. James4, Sally Young4, Hans Nieland5 and Zoltán Hantos2   Affiliations: ¹Dept of Respiratory Medicine, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium. ²Dept of Medical Physics and Informatics, University of Szeged, Szeged, Hungary. ³Dept of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, and […]