Accede a este contenido :


Background and objective

In 2014, a 6-week-long fire at the Hazelwood coal mine exposed residents in the adjacent town of Morwell to high concentrations of fine particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5 ). The long-term health consequences are being evaluated as part of the Hazelwood Health Study.


Approximately 3.5-4 years after the mine fire, adults from Morwell (n = 346) and the comparison town Sale (n = 173) participated in the longitudinal Respiratory Stream of the Study. Individual PM2.5 exposure was retrospectively modelled. Lung mechanics were assessed using the forced oscillation technique (FOT), utilizing pressure waves to measure respiratory system resistance (Rrs) and reactance (Xrs). Multivariate linear regression was used to evaluate associations between PM2.5 and transformed Rrs at 5 Hz, area under the reactance curve (AX5) and Xrs at 5 Hz controlling for key confounders.


There were clear dose-response relationships between increasing mine fire PM2.5 and worsening lung mechanics, including a reduction in post-bronchodilator (BD) Xrs5 and an increase in AX5. A 10 μg/m3 increase in mine fire-related PM2.5 was associated with a 0.015 (95% CI: 0.004, 0.027) reduction in exponential (Xrs5) post-BD, which was comparable to 4.7 years of ageing. Similarly, the effect of exposure was associated with a 0.072 (0.005, 0.138) increase in natural log (lnAX5) post-BD, equivalent to 3.9 years of ageing.


This is the first study using FOT in adults evaluating long-term respiratory outcomes after medium-term ambient PM2.5 exposure to coal mine fire smoke. These results should inform public health policies and planning for future events.


Holt NR, Gao CX, Borg BM, Brown D, Broder JC, Ikin J, et al. Long-term impact of coal mine fire smoke on lung mechanics in exposed adults. Respirology [Internet]. 2021 Sep 1 [cited 2021 Oct 24];26(9):861–8

Déjenos saber cómo le podemos asistir. Nos encantaría escucharlo.
¿Interesado en los productos de THORASYS? Contáctenos para tener una cotización personalizada.
Mensaje enviado con éxito.
Nos contactaremos lo más pronto posible.