Entries by Eve-Gabrielle Bissonnette

Non-invasive measure of mechanics & conventional respiratory in animals by Airwave Oscillometry

Introduction A number of drugs in clinical trials are discontinued due to potentially life-threatening airway obstruction. As some drugs may not cause changes in core battery parameters such as tidal volume (Vt), respiratory rate (RR) or minute ventilation (MV), including measurements of respiratory mechanics in safety pharmacology studies represents an opportunity for design refinement. The […]

Within-breath resistance & reactance in two forced oscillation technique devices

Introduction: The forced oscillation technique (FOT) is gaining clinical importance as a lung function test with the increasing availability of commercial devices. Device comparisons have been made but not in within-breath parameters. Aim: To compare total, inspiratory and expiratory resistance (Rrs) and reactance (Xrs) between two commercial FOT devices. Methods: 12 healthy subjects performed 3 […]

Oscillometry system comparison in phantoms and humans

Objective: This study compares an Impulse Oscillometry System (IOS; CareFusion) and an Airwave Oscillometry System (tremoFlo; THORASYS) in phantoms and humans. Methods: We built and characterized 3 phantoms representative of normal and obstructed human respiratory systems. Each was measured thrice per device, and averages of resistance (R) and reactance (X) versus frequency (IOS: 5-35 Hz; […]

Statistical model to estimate lung density utilizing oscillometry, biometrics, PROs & PFT

Quantitative CT is used to estimate LD but is not always available. We hypothesized that non-radiological parameters gathered in clinical practice may predict LD. 136 COPD subjects from a respirology practice completed PRO (mMRC and COPD Assessment Tests), PFT (Jaeger or Vmax22, Carefusion, Germany), OS (tremoFlo C-100, Thorasys, Canada) and a non-research CT scan within […]

Assessing response to methacholine challenges using a new forced oscillation device

Introduction: The forced oscillation technique (FOT) is ideal for assessing airway hyperresponsiveness, as it does not require maximal breathing manoeuvres that may affect airway tone. Previous studies have examined FOT responses to methacholine, however new commercial FOT devices mean new cut-points are needed. Aim: Compare FEV1 vs FOT responses to a methacholine challenge using a […]

Patient Reported Outcomes Correlate Better with Intra-Breath than with Whole-Breath FOT Parameters

Intra-breath (IB) FOT parameters (measured between the 0-flow points at end-expiration and end-inspiration) may better reflect deranged lung mechanics than whole-breath (WB). While PROs like spirometry, correlate weakly-moderately with WB FOT parameters, the correlation between PROs and IB parameters is unknown. We hypothesized PROs would correlate more strongly with IB than WB FOT parameters. 50 […]

Frequency dependence of resistance using patient-specific 3D physical model & a computational model

Background: Frequency dependence of resistance derived from forced oscillation technique is a potential small airways dysfunction/early airways obstruction tool. However the structural basis of this measurement has not been fully elucidated. Methods: We sought to evaluate the central airway contribution to frequency dependence of resistance, measured with Impulse Oscillometry (IOS: R5-R20) and Sinusoidal Forced Oscillations […]

Assessment of Airway Distensibility by the Forced Oscillation Technique

A non-invasive index of airway distensibility is required to track airway remodeling over time. The forced oscillation technique (FOT) provides such an index by measuring the change in respiratory system conductance at 5 Hz over the corresponding change in lung volume (ΔGrs5/ΔVL). To become useful clinically, this method has to be reproducible and easy to […]